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the p38mapk small molecule inhibitor cdd-111  (Confluence Life Sciences)

 
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    Structured Review

    Confluence Life Sciences the p38mapk small molecule inhibitor cdd-111
    (A) Western blot analysis demonstrating that SB203580 treatment inhibits <t>p38MAPK</t> activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
    The P38mapk Small Molecule Inhibitor Cdd 111, supplied by Confluence Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/p38mapk+inhibitor+cdd-111/cdd+111/pmc04049323-548-3-11
    Average 90 stars, based on 1 article reviews
    the p38mapk small molecule inhibitor cdd-111 - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "p38MAPK plays a crucial role in stromal mediated tumorigenesis"

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    Journal: Cancer discovery

    doi: 10.1158/2159-8290.CD-13-0743

    (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
    Figure Legend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Techniques Used: Western Blot, Activity Assay

    (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.
    Figure Legend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Techniques Used: RNA Sequencing Assay, Expressing

    Related Articles

    Western Blot:

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
    Article Snippet: p38MAPK inhibitors have entered phase II clinical trails for rheumatoid arthritis and thus have proven safe in a nonlethal disease ( 36 ) ( 37 ). .. We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow. .. CDD-111 was chosen because it can be orally administered and shows high specificity for the p38MAPK α subunit ( 38 ).

    Activity Assay:

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
    Article Snippet: p38MAPK inhibitors have entered phase II clinical trails for rheumatoid arthritis and thus have proven safe in a nonlethal disease ( 36 ) ( 37 ). .. We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow. .. CDD-111 was chosen because it can be orally administered and shows high specificity for the p38MAPK α subunit ( 38 ).

    Phospho-proteomics:

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
    Article Snippet: p38MAPK inhibitors have entered phase II clinical trails for rheumatoid arthritis and thus have proven safe in a nonlethal disease ( 36 ) ( 37 ). .. We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow. .. CDD-111 was chosen because it can be orally administered and shows high specificity for the p38MAPK α subunit ( 38 ).

    Control:

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
    Article Snippet: p38MAPK inhibitors have entered phase II clinical trails for rheumatoid arthritis and thus have proven safe in a nonlethal disease ( 36 ) ( 37 ). .. We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow. .. CDD-111 was chosen because it can be orally administered and shows high specificity for the p38MAPK α subunit ( 38 ).

    RNA Sequencing:

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
    Article Snippet: p38MAPK inhibitors have entered phase II clinical trails for rheumatoid arthritis and thus have proven safe in a nonlethal disease ( 36 ) ( 37 ). .. We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow. .. CDD-111 was chosen because it can be orally administered and shows high specificity for the p38MAPK α subunit ( 38 ).

    Expressing:

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis
    Article Snippet: p38MAPK inhibitors have entered phase II clinical trails for rheumatoid arthritis and thus have proven safe in a nonlethal disease ( 36 ) ( 37 ). .. We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow. .. CDD-111 was chosen because it can be orally administered and shows high specificity for the p38MAPK α subunit ( 38 ).



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    the p38mapk small molecule inhibitor cdd-111  (Confluence Life Sciences)
    90
    Confluence Life Sciences the p38mapk small molecule inhibitor cdd-111
    (A) Western blot analysis demonstrating that SB203580 treatment inhibits <t>p38MAPK</t> activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
    The P38mapk Small Molecule Inhibitor Cdd 111, supplied by Confluence Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/p38mapk+inhibitor+cdd-111/cdd+111/pmc04049323-548-3-11
    Average 90 stars, based on 1 article reviews
    the p38mapk small molecule inhibitor cdd-111 - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    p38mapk inhibitor cdd-111  (Confluence Life Sciences)
    90
    Confluence Life Sciences p38mapk inhibitor cdd-111
    (A) Western blot analysis demonstrating that SB203580 treatment inhibits <t>p38MAPK</t> activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
    P38mapk Inhibitor Cdd 111, supplied by Confluence Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/p38mapk+inhibitor+cdd-111/cdd+111/pmc04049323-211-3-14
    Average 90 stars, based on 1 article reviews
    p38mapk inhibitor cdd-111 - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier
    p38mapk small molecule inhibitor cdd-111  (Confluence Life Sciences)
    90
    Confluence Life Sciences p38mapk small molecule inhibitor cdd-111
    (A) Western blot analysis demonstrating that SB203580 treatment inhibits <t>p38MAPK</t> activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.
    P38mapk Small Molecule Inhibitor Cdd 111, supplied by Confluence Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/p38mapk+inhibitor+cdd-111/cdd+111/pmc04049323-548-6-11
    Average 90 stars, based on 1 article reviews
    p38mapk small molecule inhibitor cdd-111 - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Article Snippet: Oral dosage of p38MAPK inhibitor The p38MAPK small molecule inhibitor CDD-111 (Confluence Life Sciences, Inc, St. Louis, MO) was compounded at 516 ppm with Purina Rodent Chow #5001 (St. Louis, MO) to generate a daily exposure of 80 mg/kg/day.

    Techniques: Western Blot, Activity Assay

    (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Article Snippet: Oral dosage of p38MAPK inhibitor The p38MAPK small molecule inhibitor CDD-111 (Confluence Life Sciences, Inc, St. Louis, MO) was compounded at 516 ppm with Purina Rodent Chow #5001 (St. Louis, MO) to generate a daily exposure of 80 mg/kg/day.

    Techniques: RNA Sequencing Assay, Expressing

    (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Article Snippet: We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow.

    Techniques: Western Blot, Activity Assay, Phospho-proteomics, Control

    (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Article Snippet: We obtained a p38MAPK inhibitor (CDD-111, also referred to as SD-0006 ( 38 ), Confluence Life Sciences) and compounded it into mouse chow.

    Techniques: RNA Sequencing, Expressing

    (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) Western blot analysis demonstrating that SB203580 treatment inhibits p38MAPK activity. As expected, SB203580 treatment significantly impacts phosphorylation of p38MAPK’s direct downstream target, Hsp27. Total Hsp27 was used as loading control.

    Article Snippet: Oral dosage of p38MAPK inhibitor The p38MAPK small molecule inhibitor CDD-111 (Confluence Life Sciences, Inc, St. Louis, MO) was compounded at 516 ppm with Purina Rodent Chow #5001 (St. Louis, MO) to generate a daily exposure of 80 mg/kg/day.

    Techniques: Western Blot, Activity Assay, Phospho-proteomics, Control

    (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Journal: Cancer discovery

    Article Title: p38MAPK plays a crucial role in stromal mediated tumorigenesis

    doi: 10.1158/2159-8290.CD-13-0743

    Figure Lengend Snippet: (A) RNA-seq analysis was performed on young fibroblasts, senescent fibroblasts, and senescent fibroblasts treated with SB203580. RNA-seq results were analyzed to determine the number of factors upregulated in response to senescence (SASP factors) and the number of p38MAPK-dependent factors. These results were also analyzed for overlap with the expression profiles of breast cancer (BC)-associated stroma.

    Article Snippet: Oral dosage of p38MAPK inhibitor The p38MAPK small molecule inhibitor CDD-111 (Confluence Life Sciences, Inc, St. Louis, MO) was compounded at 516 ppm with Purina Rodent Chow #5001 (St. Louis, MO) to generate a daily exposure of 80 mg/kg/day.

    Techniques: RNA Sequencing, Expressing